紹介記事・論文

主要原著論文

332011-09-20

Takeshi Todoroki, Tadashi Kondo, Shinji Sugahara, Yukio Morishita, Kensaku Mori and Tadao Ohno: Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy. World Journal of Surgical Oncology 2011, 9:96

322011-05-02

Noriaki SAKAMOTO, Eiichi ISHIKAWA, Tetsuya YAMAMOTO, Kaishi SATOMI, Kei NAKAI, Masayuki SATO, Takao ENOMOTO, Yukio MORISHITA, Shingo TAKANO, Tadao OHNO, Koji TSUBOI, and Akira MATSUMURA: Pathological Changes After Autologous Formalin-Fixed Tumor Vaccine Therapy Combined With Temozolomide for Glioblastoma -Three Case Reports-. Neurol Med Chir (Tokyo) 51, 319-325, 2011.

312011-04-15

Yoshihiro Muragaki, Takashi Maruyama, Hiroshi Iseki, Masahiko Tanaka, Chie Shinohara, Kintomo Takakura, Koji Tsuboi, Tetsuya Yamamoto, Akira Matsumura, Masao Matsutani, Katsuyuki Karasawa, Katsunori Shimada, Naohito Yamaguchi, Yoichi Nakazato, Keiki Sato, Yoji Uemae, Tadao Ohno, and Tomokatsu Hori:
Phase I / IIa Trial of Autologous Formalin-fixed Tumor Vaccine Concomitant with Fractionated Radiotherapy for Initially-Diagnosed Glioblastoma.
J. NeuroSurgery, J Neurosurg. 2011 Aug;115(2):248-55. (e-pub ahead, 2011.05)

302007-12-31

Harada H , Goto Y , Ohno T , Suzu S , Okada S . Proliferative activation up-regulates expression of CD4 and HIV-1 co-receptors on NK cells and induces their infection with HIV-1. Eur. J. Immunol., (2007), 37, 2184-2155.

292007-12-31
Ishikawa, Eiichi; Tsuboi, Koji; Yamamoto, Tetsuya; Muroi, Ai; Enomoto, Takao; Takano, Shingo; Matsumura, Akira; Ohno, Tadao: A clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients. Cancer Sci., 98(8):1226-1233, 2007.
282005-07-30
Tsurushima H, Yoshii Y, Leong KW, Ohno T.: Targeted tumor cell death induced by autologous tumor-Specific T lymphocyte recognition of wild-type p53-derived peptides. J Neurooncol. 2005 Jul 30; [Epub ahead of print] .
272004-12-11
Kawai K, Saijo K, Oikawa T, Ohno T, Akaza H.: Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression. Int J Urol. Dec;11(12):1130-2, 2004.
262005-12-31

Ghosh, M., Koike, N., Tsunoda, S., Hirano, T., Kaul, S., Kashiwagi, H., Kawamoto, T., Ohkohchi, N., Saijo, K., Ohno, T., Miwa, M., and Todoroki, T.: Characterization and genetic analysis in the newly established human bile duct cancer cell lines. Int. J. Oncol. 26:449-456, 2005.

252004-12-31

Ishikawa, E., Tsuboi, K., Saijo, K.,Harada, H., Takano, S., Nose, T., Ohno, T.: Autologous Natural Killer Cell Therapy for Human Recurrent Malignat Glioma. Anticancer Research. 24: 1861-1872, 2004.

242004-12-31

Ishikawa, E., Tsuboi, K., Saijo, K., Takano, S., and Ohno, T.: X-irradiation to human malignant glioma cells enhances the cytotoxicity of autologous killer lymphocytes under specific conditions. Int. J. Radiation Oncology Biol. Phys. 59: 1505-1512, 2004.

232004-12-31

Harada, H., Watanabe, S., Saijo, K., Ishiwata, I., and Ohno, T.: A Wilms tumor cell line, HFWT, can greatly stimulate proliferation of CD56+ human natural killer cells and their novel precursors in blood mononuclear cells. Exp. Hematol. 32: 614-621, 2004.

222004-12-31

Harada, H., Saijo, K., Ishiwata, I., and Ohno, T.: A GFP-transfected HFWT cell line, GHINK-1, as a novel target for non-RI activated natural killer cytotoxicity assay. Human Cell, 17: 43-48, 2004.

212004-12-31

Kushida, S., Peng, B. G., Uchimura, E., Kuang, M., Huang, L., Miwa, M., and Ohno, T.: A tumor vaccine of fixed tumor fragments in a controlled-release vehicle with cytokines for therapy of hepatoma in mice. Digestive and Liver Disease, 36: 478-485, 2004.

202004-03-12

Ming Kuang, Bao G. Peng, Ming D. Lu, Li J. Liang, Jie F. Huang, Qiang He, Yun P. Hua, Saeri Totsuka, Shu Q. Liu, Kam W. Leong and Tadao Ohno*: Phase II Randomized Trial of Autologous Formalin-Fixed Tumor Vaccine for Postsurgical Recurrence of Hepatocellular Carcinoma. Clin. Cancer Res. 10: 1574-1579, 2004.

192004-12-31

Mila Ghosh, Naoto Koike, Go Yanagimoto, Shin-ichi Tsunoda, Sunil Kaul, Takashi Hirano, Fabian Emura, Hironobu Kashiwagi, Toru Kawamoto, Nobuhiro Ohkohchi, Kaoru Saijo, Tadao Ohno, Masanao Miwa, and Takeshi Todoroki*: Establishment and characterization of unique human gallbladder cancer cell lines. Int'l. J. Oncol. 24: 1189-1196, 2004.

182004-12-31

Eiichi Ishikawa , Koji Tsuboi , Shingo Takano , Eiji Uchimura , Tadao Nose, and Tadao Ohno*: Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of an intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model. Cancer Sci. 95: 98-103, 2004.

172003-12-31

Fabian Emura, Hiroshi Kamma, Mila Ghosh, Naoto Koike, Toru Kawamoto, Kaoru Saijo, Tadao Ohno, Nobuhiro Ohkohchi, and Takeshi Todoroki*: Establishment and characterization of novel xenograft models of human biliary tract carcinomas. Int'l. J. Oncol. 23: 1293-1300, 2003.

162003-12-31

Koji Tsuboi*, Kaoru Saijo, Eiichi Ishikawa, Hideo Tsurushima, Shingo Takano, Yukio Morishita and Tadao Ohno: Effects of Local Injection of ex Vivo Expanded Autologous Tumor-specific T Lymphocytes in Cases with Recurrent Malignant Gliomas. Clinical Cancer Research, 9: 3294-3302, 2003.

152002-12-31

Peng, B. G., Liu, S. Q., Kuang, M., He, Q., Totsuka, S., Huang, L., Huang, J., Lu, M-D., Liang, L-J., Leong, K. W., and Ohno, T.*: Autologous fixed tumor vaccine: A formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma. Jpn. J. Cancer Res. 93: 363-8, 2002.

142002-12-31

Harada, H., Saijo, K., Watanabe, S., Tsuboi, K., Nose, T., Ishiwata, I., Ohno, T.*: Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT. Jpn. J. Cancer Res. 93: 313-9, 2002.

132001-12-31

Masters, J. R.*, Thomson, J. A., Daly-Burns, B., Reid, Y. A., Dirks, W. G., Packer, P., Toji, L. H., Ohno, T., Tanabe, H., Arlett, C. F., Kelland, L. R., Harrison, M., Virmani, A., Ward, T. H., Ayres, K. L., Debenham, P. G.: Short tandem repeat profiling provides an international reference standard for human cell lines. Proc. Natl. Acad. Sci., U S A. 98: 8012-7, 2001.

122000-12-31

Kim, C. H., Todoroki, T., Matsumura, M., and Ohno, T.*: Eligibility of antigenic-peptide pre-loaded and fixed adhesive peripheral blood cells for induction of cytotoxic T lymphocytes for cancer patients with elevated serum CEA levels. J. Cancer Res. Clin. Oncol., 126: 383-390, 2000.

111999-12-31

Tsurushima, H., Liu, S. Q., Tuboi, K., Matsumura, A., Yoshii, Y., Nose, T., Saijo, K. and Ohno, T.*: Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes. Jpn. J. Cancer Res.., 9, 536-545, 1999.

101999-12-31

Saijo, Y.*, Hong, X., Tanaka, M., Tazawa, R., Liu, S. Q., Saijo, K., Ohno, T., Koike, K., Ohkuda, K., Saitoh, K., and Nukiwa, T.: Autologous high-killing cytotoxic T lymphocytes against human lung cancer are induced using interleukin (IL)-1b, IL-2, IL-4, and IL-6: Possible involvement of dendritic cells. Clinical Cancer Research, 5, 1203-1209, 1999.

091998-12-31

Liu, S. Q., Kawai, K., Shiraiwa, H., Hayashi, H. Akaza, H., Hashizaki, K., Shiba, R., Saijo, K., Ohno, T.*: High rate of induction of human autologous cytotoxic T lymphocytes against renal carcinoma cells cultured with an interleukin cocktail. Jpn. J. Cancer Res., 89: 1195-1201, 1998.

081998-12-31

Kohyama, M., Saijo, K., Hayashida, M., Yasugi, T., Kurimoto, M., and Ohno, T.*: Direct activation of human CD8+ cytotoxic T lymphocytes by interelukin-18. Jpn. J. Cancer Res., 89: 1041-1046, 1998.

071998-12-31

Kim, C., Matsumura, M., Saijo, K., Ohno, T.*: In vitro induction of HLA-A2402-restricted and carcinoembryonic-antigen-specific cytotoxic T lymphocytes on fixed autologous peripheral blood cells. Cancer Immunol. Immunother., 47: 90-96, 1998.

061997-12-31

Horiuchi, K., Tsurushima, H., Kim, B. S., Liu, S. Q., Saijo, K., Saijo, Y., Nukiwa, T., Nomura, N., Matsumura, M., Ohno, T.*: Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells. Cytotechnology, 26, 119-124, 1997.

051996-12-31

Tsurushima, H., Liu, S. Q., Tsuboi, K., Yoshii, Y., Nose, T. and Ohno, T.*: Induction of human autologous cytotoxic T lymphocytes on minced tissues of the brain tumor, glioblastoma multiforme. J. Neurosurgery, 84, 258-263, 1996.

041996-12-31

Liu, S. Q., Shiraiwa, H., Kawai, K., Hayashi, H., Akaza, H., Kim, B. S., Oki, A., Nishida, M., Kubo, T., Hashizaki, K., Saijo, K. and Ohno, T.*: Tumor-specific autologous cytotoxic T lymphocytes from tissue sections. Nature Medicine, 2: 1283-1283, 1996.

031995-12-31

Liu, S. Q., Saijo, K., Todoroki, T., and Ohno, T.* : Induction of human autologous cytotoxic T lymphocytes on formalin-fixed and paraffin-embedded tumour sections. Nature Medicine, 1, 267-271, 1995.

021994-12-31

Liu, S. Q., Shiba, R. Kim, B. S., Saijo, K. and Ohno, T.* : Long-term serum/plasma-free culture of human cytotoxic T lymphocytes induced from peripheral blood mononuclear cells. Cancer Immunol. Immunother., 39, 279-285, 1994.

011992-12-31

Kawai, K., Sasaki, T., Saijo-Kurita, K., Akaza, H., Koiso, K., and Ohno, T.*: Additive effects of antitumor drugs and lymphokine-activated killer cell cytotoxic activity in tumor cell killing determined by lactate-dehydrogenase assay. Cancer Immunol. Immunother., 35:225-229, 1992.